鄭菡若老師 神經系統疾病實驗室

Master Student

蘇子晴
Sunny
探討人類CD33參與阿茲海默症小鼠的病程發展

The Involvement of human CD33 in the pathogenesis of Alzheimer’s disease mouse model

林源晟
Luis
探討不同濃度的ENERGI在阿茲海默症小鼠模型中對於記憶和病理的影響

Investigation of the dose-dependent effect of ENERGI on memory and pathology in an Alzheimer’s disease mouse model

張耘瑋
Jacky
探討微膠細胞中CASK缺失對澱粉樣蛋白清除之機制

Dissecting the mechanisms of CASK deficiency on the clearance of Aβ in microglia

孫瑋駿
Wayne
探討FGFR1的活化劑FGL在阿茲海默症小鼠模式之作用

The effect of FGFR1 agonist FGL in Alzheimer’s disease mouse model

江芊妤
Kate
探討恐懼制約後小鼠海馬迴不同的抑制型中間神經元的基因表現之改變

Changes of gene expression in mouse hippocampal Parvalbumin+ and Somatostatin+ interneurons after fear conditioning

高鈺修
Matthew
修哥 Show girl
探討AMPK活化劑ENERGI來減緩阿茲海默症小鼠記憶與病理缺失

Investigating an AMPK agonist ENERGI on the memory and pathological deficits in a mouse model of Alzheimer’s disease

卓晏廷
Julie
小白
利用阿茲海默症細胞模型探討 CASK 在微膠細胞中的角色

The Role of Calcium/Calmodulin-Dependent Serine Protein Kinase (CASK) on Microglial Activation in Cellular Model of Alzheimer’s Disease

于士逵
Alex
海龜
探討纖維母細胞生長因子23在阿茲海默症小鼠的角色

Exploring the role of FGF23 in AD animal model

洪維謙
Charlie
Hung WC
Psyduck
Charlie candy mountain
探討纖維母細胞生長因子1對阿茲海默小鼠的影響

Investigate the effects of fibroblast growth factor 1 in Alzheimer’s disease mouse model
Lu YS*, Hung WC*, Hsieh YT, Tsai PY, Tsai TH, Fan HH, Chang YG, Cheng HK, Huang SY, Lin HC, Lee YH, Shen TH, Hung BY, Tsai JW, Dzhagalov I, Cheng IH, Lin CJ, Chern Y, Hsu CL. Equilibrative nucleoside transporter 3 supports microglial functions and protects against the progression of Huntington’s disease in the mouse model.
Brain Behav Immun. 2024 Jun 24;120:413-429. 

鄧昕孟 

Deng SM

探討透過益生質及共生質調控腸道菌叢對阿茲海默症小鼠的影響

Investigate the Effects of Microbiota Modulation via Prebiotic and Synbiotic on Alzheimer’s Disease Mouse Model

Deng SM, Chen CJ, Lin HL, Cheng IH. The beneficial effect of synbiotics consumption on Alzheimer’s disease mouse model via reducing local and systemic inflammation.
IUBMB Life. 2022 Aug;74(8):748-753.

陳偵綾  學習刺激對阿茲海默小鼠功能和病理缺陷的影響

The effect of learning stimulation on functional and pathological deficits in hAPP transgenic mice

黃子瑄
Lisa
Huang TH
探討環境豐富化對小鼠 Parvalbumin 及 Somatostatin 陽性神經元基因表現之影響

Investigate the Effect of Enriched Environment on the Gene Expression of Parvalbumin- and Somatostatin-Positive Interneurons in Mice

Huang TH, Lin YS, Hsiao CW, Wang LY, Ajibola MI, Abdulmajeed WI, Lin YL, Li YJ, Chen CY, Lien CC, Chiu CD, Cheng IH. Differential expression of GABAA receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus.
Front Cell Neurosci. 2023 Jul 20;17:1146278.

Lee ZF, Huang TH, Chen SP, Cheng IH. Altered nociception in Alzheimer disease is associated with striatal-enriched protein tyrosine phosphatase signaling.
Pain. 2021 Jun 1;162(6):1669-1680.

李倧輔
Jeff
Lee ZF
探討阿茲海默症小鼠的痛覺變化及其成因

Altered Nociception in A Transgenic Mouse Model of Alzheimer’s Disease

Lee ZF, Huang TH, Chen SP, Cheng IH. Altered nociception in Alzheimer disease is associated with striatal-enriched protein tyrosine phosphatase signaling.
Pain. 2021 Jun 1;162(6):1669-1680.

黃筱涵 pERK 在急性與慢性疼痛小鼠模式中的變化

Level of pERK in Acute Pain and Chronic Pain Mouse Models

柯婷翎 探討阿茲海默症相關病理蛋白質在散發型及家族遺傳型檢體中之變化

The Changes of Pathological Proteins in Sporadic and Familial Alzheimer’s Disease Samples

戴宜珩
Tai YH
探討液態奈米化薑黃素在阿茲海默症小鼠的影響

The Effects of Curcumin Submicron Particles in Alzheimer’s Disease Mouse Model

Tai YH, Lin YY, Wang KC, Chang CL, Chen RY, Wu CC, Cheng IH. Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer’s disease mouse model.
Oncotarget. 2018 Jan 31;9(12):10681-10697.

吳語婕 藉由大腦灰質體積、認知表現、血漿類澱粉蛋白量偵測患者由輕微認知功能損傷至阿茲海默氏症之轉變

Detection of Conversion from Patients with Mild Cognitive Impairment to Alzheimer’s Disease, via Gray Matter Atrophy, Plasma Aβ42, and Cognitive Performance

林哲慶 Presenilin 1 在壓力下對細胞存活所扮演之角色

The Role of Presenilin 1 in Cell Survival Under Stress

王家儀 探討阿茲海默氏症中類澱粉前驅蛋白突變所造成的機制

The Pathogenic of Aβ N-terminal Mutations in APP Processing and Localization

吳亞縈 特殊表現型及神經精神症狀在阿茲海默症生物標記之研究

Specific Phenotype and Neuropsychiatric Symptoms in Biomarkers Studies of Alzheimer’s Disease

謝宜芳
Hsieh YF
家族性阿茲海默氏症Presenilin 1 G206D突變的特性

The Characterization of Presenilin 1 with G206D Mutation Associated with Familial Alzheimer’s Disease

Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
Mol Neurobiol. 2015 Dec;52(3):1835-1849.

Chen WT, Hong CJ, Lin YT, Chang WH, Huang HT, Liao JY, Chang YJ, Hsieh YF, Cheng CY, Liu HC, Chen YR, Cheng IH. Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies.
PLoS One. 2012;7(4):e35807.

黃靖雯 與阿茲海默症疾病嚴重度相關之可能的血清生物標記

Potential Serum Biomarker for Disease Severity in Alzheimer’s Disease

黃荷婷 新型家族性阿茲海默症突變改變類澱粉前驅蛋白之代謝

The Alteration in Amyloid Precursor Protein Metabolism Induced by a Novel Familial Alzheimer’s Disease Mutation

陳暐婷
Chen WT
金屬離子及病理性突變對類澱粉乙型蛋白折疊、寡倍體化及纖維化過程的影響

Distinct Effect of Metal Ions and a Pathogenic Mutation on Amyloid Beta Folding, Oligomerization and Fibrillization Process

Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
Mol Neurobiol. 2015 Dec;52(3):1835-1849.

林雅梓 探討新的類澱粉蛋白突變對其代謝型式的改變

The Effect of a Novel Mutation on Amyloid Precursor Protein Processing

林依靜 第六型膠原蛋白對於紫外線引發的神經細胞凋亡之保護作用

Protective Effect of Collagen VI Against Apoptosis Due to UV-induced Damage in Neuron