 |
林鈺益 |
Lin YY, Chang WH, Hsieh SL, Cheng IH. The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model. J Neuroinflammation. 2024 Oct 23;21(1):273. Tai YH, Lin YY, Wang KC, Chang CL, Chen RY, Wu CC, Cheng IH. Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer’s disease mouse model. Liu YL, Chen WT, Lin YY, Lu PH, Hsieh SL, Cheng IH. Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model. |
 |
李宜蓉 Lee YJ |
認知功能正常者血液生物標誌對認知功能減退之預測 Predictive utility of plasma biomarkers for cognitive decline in cognitively normal adults Lee YJ, Lin SY, Peng SW, Lin YC, Chen TB, Wang PN, Cheng IH. Predictive Utility of Plasma Amyloid and Tau for Cognitive Decline in Cognitively Normal Adults. J Prev Alzheimers Dis. 2023;10(2):178-185. Chen TB, Lai YH, Ke TL, Chen JP, Lee YJ, Lin SY, Lin PC, Wang PN, Cheng IH. Changes in Plasma Amyloid and Tau in a Longitudinal Study of Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease. Dement Geriatr Cogn Disord. 2019;48(3-4):180-195. Chen TB, Lee YJ, Lin SY, Chen JP, Hu CJ, Wang PN, Cheng IH. Plasma Aβ42 and Total Tau Predict Cognitive Decline in Amnestic Mild Cognitive Impairment. Sci Rep. 2019 Sep 27;9(1):13984. |
 |
林丹妮 Tania Devina |
以APP D678H突變型誘導性多功能幹細胞研究內質網壓力與長鏈非編碼RNA對阿茲海默症致病機轉的影響 The effects of ER stress and lncRNA Yam-1 in Alzheimer’s Disease pathogenesis using the neuron derived from iPSC with APP D678H mutation Devina T, Wong YH, Hsiao CW, Li YJ, Lien CC, Cheng IH. Endoplasmic reticulum stress induces Alzheimer disease-like phenotypes in the neuron derived from the induced pluripotent stem cell with D678H mutation on amyloid precursor protein. J Neurochem. 2022 Oct;163(1):26-39. Wu PC, Fann MJ, Tran TT, Chen SC, Devina T, Cheng IH, Lien CC, Kao LS, Wang SJ, Fuh JL, Tzeng TT, Huang CY, Shiao YJ, Wong YH. Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer’s disease using patient iPSC-derived neurons. Sci Rep. 2019 Dec 17;9(1):19301. |
 |
陳廷斌 Chen TB |
輕度認知障礙與阿茲海默氏症之縱貫性血漿生物標記變化及其臨床意義 Longitudinal Plasma Biomarker Trajectories and Their Clinical Implications in Mild Cognitive Impairment and Alzheimer Disease Chen TB, Lai YH, Ke TL, Chen JP, Lee YJ, Lin SY, Lin PC, Wang PN, Cheng IH. Changes in Plasma Amyloid and Tau in a Longitudinal Study of Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease. Dement Geriatr Cogn Disord. 2019;48(3-4):180-195. Chen TB, Lee YJ, Lin SY, Chen JP, Hu CJ, Wang PN, Cheng IH. Plasma Aβ42 and Total Tau Predict Cognitive Decline in Amnestic Mild Cognitive Impairment. Sci Rep. 2019 Sep 27;9(1):13984. |
 |
劉怡伶 Liu YL |
利用阿茲海默氏症細胞與動物模式研究 DcR3/TNFRSF6B 對於類澱粉造成神經退化之影響 Amelioration of amyloid-β-induced deficits by DcR3/TNFRSF6B in an Alzheimer’s disease model Liu YL, Chen WT, Lin YY, Lu PH, Hsieh SL, Cheng IH. Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model. Mol Neurodegener. 2017 Apr 24;12(1):30. Cheng IH, Lin YC, Hwang E, Huang HT, Chang WH, Liu YL, Chao CY. Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/phosphatidylinositol 3-kinase signaling pathway. Neuroscience. 2011 Jun 2;183:178-88. |
 |
張文瀚 Chang WH |
利用飲食或基因上之方法來調控阿茲海默症小鼠之氧化壓力、神經發炎以及神經退化現象 Using Dietary or Genetic Approaches to Ameliorate Oxidative Stress, Neuroinflammation, and Neurodegeneration in Alzheimer’s Disease Mouse Model Chang WH, Chen MC, Cheng IH. Antroquinonol Lowers Brain Amyloid-β Levels and Improves Spatial Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease. Sci Rep. 2015 Oct 15;5:15067. Chen WT, Hong CJ, Lin YT, Chang WH, Huang HT, Liao JY, Chang YJ, Hsieh YF, Cheng CY, Liu HC, Chen YR, Cheng IH. Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies. PLoS One. 2012;7(4):e35807. Chu YF, Chang WH, Black RM, Liu JR, Sompol P, Chen Y, Wei H, Zhao Q, Cheng IH. Crude caffeine reduces memory impairment and amyloid β(1-42) levels in an Alzheimer’s mouse model. Cheng IH, Lin YC, Hwang E, Huang HT, Chang WH, Liu YL, Chao CY. Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/phosphatidylinositol 3-kinase signaling pathway. Neuroscience. 2011 Jun 2;183:178-88. |
|
陳暐婷 Chen WT |
臺灣家族性阿茲默症基因突變的致病機轉 Pathogenic Mechanisms of Familial Alzheimer’s Disease: Amyloid Precursor Protein D678H mutation and Presenilin-1 G206D mutation in Taiwanese pedigrees Liu YL, Chen WT, Lin YY, Lu PH, Hsieh SL, Cheng IH. Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model.Mol Neurodegener. 2017 Apr 24;12(1):30. Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation. Mol Neurobiol. 2015 Dec;52(3):1835-1849. Chen WT, Hong CJ, Lin YT, Chang WH, Huang HT, Liao JY, Chang YJ, Hsieh YF, Cheng CY, Liu HC, Chen YR, Cheng IH. Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies. PLoS One. 2012;7(4):e35807. Chen WT, Liao YH, Yu HM, Cheng IH, Chen YR. Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation. J Biol Chem. 2011 Mar 18;286(11):9646-56. |