鄭菡若老師 神經系統疾病實驗室

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Lu YS, Hung WC, Hsieh YT, Tsai PY, Tsai TH, Fan HH, Chang YG, Cheng HK, Huang SY, Lin HC, Lee YH, Shen TH, Hung BY, Tsai JW, Dzhagalov I, Cheng IH, Lin CJ, Chern Y, Hsu CL. Equilibrative nucleoside transporter 3 supports microglial functions and protects against the progression of Huntington’s disease in the mouse model.
Brain Behav Immun. 2024 Jun 24;120:413-429.
Chiu CD, Chiu YP, Yip HT, Ji HR, Cho DY, Cheng IH, Chen CY. Thiazolidinediones Decrease the Recurrence of Intracerebral Hemorrhage in Type 2 Diabetes Mellitus Patients: A Nested Case-Control Study.
Neuroepidemiology. 2024 May 3:1-14.
Cheong KJH, Huang DY, Sekar P, Chen RJ, Cheng IH, Chan CM, Chen YS, Lin WW. CASK Mediates Oxidative Stress-Induced Microglial Apoptosis-Inducing Factor-Independent Parthanatos Cell Death via Promoting PARP-1 Hyperactivation and Mitochondrial Dysfunction.
Antioxidants (Basel). 2024 Mar 13;13(3):343.
Huang TH, Lin YS, Hsiao CW, Wang LY, Ajibola MI, Abdulmajeed WI, Lin YL, Li YJ, Chen CY, Lien CC, Chiu CD, Cheng IH. Differential expression of GABAA receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus.
Front Cell Neurosci. 2023 Jul 20;17:1146278.
Lee YJ, Lin SY, Peng SW, Lin YC, Chen TB, Wang PN, Cheng IH. Predictive Utility of Plasma Amyloid and Tau for Cognitive Decline in Cognitively Normal Adults.
J Prev Alzheimers Dis. 2023;10(2):178-185.
Devina T, Wong YH, Hsiao CW, Li YJ, Lien CC, Cheng IH. Endoplasmic reticulum stress induces Alzheimer disease-like phenotypes in the neuron derived from the induced pluripotent stem cell with D678H mutation on amyloid precursor protein.
J Neurochem. 2022 Oct;163(1):26-39.
Abdulmajeed WI, Wang KY, Wu JW, Ajibola MI, Cheng IH, Lien CC. Connectivity and synaptic features of hilar mossy cells and their effects on granule cell activity along the hippocampal longitudinal axis.
J Physiol. 2022 Jul;600(14):3355-3381. 
Lee ZF, Huang TH, Chen SP, Cheng IH. Altered nociception in Alzheimer disease is associated with striatal-enriched protein tyrosine phosphatase signaling.
Pain. 2021 Jun 1;162(6):1669-1680.
Deng SM, Chen CJ, Lin HL, Cheng IH. The beneficial effect of synbiotics consumption on Alzheimer’s disease mouse model via reducing local and systemic inflammation.
IUBMB Life. 2022 Aug;74(8):748-753.
Chen YX, Le PTN, Tzeng TT, Tran TH, Nguyen AT, Cheng IH, Huang CF, Shiao YJ, Ching TT. Graptopetalum paraguayense Extract Ameliorates Proteotoxicity in Aging and Age-Related Diseases in Model Systems.
Nutrients. 2021 Nov 29;13(12):4317.
Chen TB, Lai YH, Ke TL, Chen JP, Lee YJ, Lin SY, Lin PC, Wang PN, Cheng IH. Changes in Plasma Amyloid and Tau in a Longitudinal Study of Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease.
Dement Geriatr Cogn Disord. 2019;48(3-4):180-195.
Kuo LC, Song YQ, Yao CA, Cheng IH, Chien CT, Lee GC, Yang WC, Lin Y. Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons.
J Agric Food Chem. 2019 Jan 9;67(1):81-89. 
Chen TB, Lee YJ, Lin SY, Chen JP, Hu CJ, Wang PN, Cheng IH. Plasma Aβ42 and Total Tau Predict Cognitive Decline in Amnestic Mild Cognitive Impairment.
Sci Rep. 2019 Sep 27;9(1):13984.
Wu PC, Fann MJ, Tran TT, Chen SC, Devina T, Cheng IH, Lien CC, Kao LS, Wang SJ, Fuh JL, Tzeng TT, Huang CY, Shiao YJ, Wong YH. Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer’s disease using patient iPSC-derived neurons.
Sci Rep. 2019 Dec 17;9(1):19301.
Tai YH, Lin YY, Wang KC, Chang CL, Chen RY, Wu CC, Cheng IH. Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer’s disease mouse model.
Oncotarget. 2018 Jan 31;9(12):10681-10697.
Liu YL, Chen WT, Lin YY, Lu PH, Hsieh SL, Cheng IH. Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model.
Mol Neurodegener. 2017 Apr 24;12(1):30.
Zhao Y, Li X, Huang T, Jiang LL, Tan Z, Zhang M, Cheng IH, Wang X, Bu G, Zhang YW, Wang Q, Xu H. Intracellular trafficking of TREM2 is regulated by presenilin 1.
Exp Mol Med. 2017 Dec 1;49(12):e405.
Yang FY, Huang SF, Cheng IH. Behavioral alterations following blood-brain barrier disruption stimulated by focused ultrasound.
Oncotarget. 2016 May 10;7(19):27916-25.
Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
Mol Neurobiol. 2015 Dec;52(3):1835-1849.
Hsu BY, Hung WL, Ho CT, Cheng IH, Hwang LS. Protective effects of sesamol and ferulic acid on the formation of endogenous trans-arachidonic acid in hAPP J20 mice.
J Funct Foods. 2015 Jun;16:378-385. 
Wu YY, Hsu JL, Wang HC, Wu SJ, Hong CJ, Cheng IH. Alterations of the Neuroinflammatory Markers IL-6 and TRAIL in Alzheimer’s Disease.
Dement Geriatr Cogn Dis Extra. 2015 Nov 24;5(3):424-34.
Chang WH, Chen MC, Cheng IH. Antroquinonol Lowers Brain Amyloid-β Levels and Improves Spatial Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease.
Sci Rep. 2015 Oct 15;5:15067.
Lin YC, Wang JY, Wang KC, Liao JY, Cheng IH. Differential regulation of amyloid precursor protein sorting with pathological mutations results in a distinct effect on amyloid-β production.
J Neurochem. 2014 Nov;131(4):407-12.
Fang YS, Tsai KJ, Chang YJ, Kao P, Woods R, Kuo PH, Wu CC, Liao JY, Chou SC, Lin V, Jin LW, Yuan HS, Cheng IH, Tu PH, Chen YR. Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.
Nat Commun. 2014 Sep 12;5:4824.
Wu CC, Tsai TH, Chang C, Lee TT, Lin C, Cheng IH, Sun MC, Chuang YJ, Chen BS. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio.
PLoS One. 2014 Jun 13;9(6):e97902.
Wu PY, Huang YY, Chen CC, Hsu TT, Lin YC, Weng JY, Chien TC, Cheng IH, Lien CC. Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory.
J Neurosci. 2013 Jan 30;33(5):1828-32.
Huang CW, Wang SJ, Wu SJ, Yang CC, Huang MW, Lin CH, Cheng IH. Potential blood biomarker for disease severity in the Taiwanese population with Alzheimer’s disease.
Am J Alzheimers Dis Other Demen. 2013 Feb;28(1):75-83.
Chen WT, Hong CJ, Lin YT, Chang WH, Huang HT, Liao JY, Chang YJ, Hsieh YF, Cheng CY, Liu HC, Chen YR, Cheng IH. Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies.
PLoS One. 2012;7(4):e35807.
Chu YF, Chen YM, Brown PH, Lyle BJ, Black RM, Cheng IH, Ou BX, Prior RL. Bioactivities of crude caffeine: Antioxidant activity, cyclooxygenase-2 inhibition, and enhanced glucose uptake.
Food Chem. 2012 Mar 15;131(2):564-568.
Chu YF, Chang WH, Black RM, Liu JR, Sompol P, Chen Y, Wei H, Zhao Q, Cheng IH. Crude caffeine reduces memory impairment and amyloid β(1-42) levels in an Alzheimer’s mouse model.
Food Chem. 2012 Dec 1;135(3):2095-102.
Cheng IH, Lin YC, Hwang E, Huang HT, Chang WH, Liu YL, Chao CY. Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/phosphatidylinositol 3-kinase signaling pathway.
Neuroscience. 2011 Jun 2;183:178-88.
Wu YY, Cheng IH, Lee CC, Chiu MJ, Lee MJ, Chen TF, Hsu JL. Clinical phenotype of G206D mutation in the presenilin 1 gene in pathologically confirmed familial Alzheimer’s disease.
J Alzheimers Dis. 2011;25(1):145-50. 
Chen WT, Liao YH, Yu HM, Cheng IH, Chen YR. Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation.
J Biol Chem. 2011 Mar 18;286(11):9646-56.
Hong CJ, Tsai PJ, Cheng CY, Chou CK, Jheng HF, Chuang YC, Yang CN, Lin YT, Hsu CW, Cheng IH, Chen SY, Tsai SJ, Liou YJ, Tsai YS. ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin.
PLoS One. 2010 Dec 9;5(12):e15333.
Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu GQ, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L. Collagen VI protects neurons against Abeta toxicity.
Nat Neurosci. 2009 Feb;12(2):119-21. 
Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce-Levie K, Cheng IH, Yu GQ, Mucke L. Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice.
J Neurosci. 2009 Feb 18;29(7):1977-86.
Chu YF, Brown PH, Lyle BJ, Chen Y, Black RM, Williams CE, Lin YC, Hsu CW, Cheng IH. Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees.
J Agric Food Chem. 2009 Oct 28;57(20):9801-8. 
Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer’s disease.
Nat Neurosci. 2008 Nov;11(11):1311-8. 
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model.
Science. 2007 May 4;316(5825):750-4. 
Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L. Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.
J Biol Chem. 2007 Aug 17;282(33):23818-28. 
Ji ZS, Müllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW. Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.
J Biol Chem. 2006 Feb 3;281(5):2683-92.
Cheng IH, Palop JJ, Esposito LA, Bien-Ly N, Yan F, Mucke L. Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.
Nat Med. 2004 Nov;10(11):1190-2.
Sawyer SL, Cheng IH, Chai W, Tye BK. Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae.
J Mol Biol. 2004 Jul 2;340(2):195-202.
Cheng IH, Roberts LA, Tye BK. Mcm3 is polyubiquitinated during mitosis before establishment of the pre-replication complex.
J Biol Chem. 2002 Nov 1;277(44):41706-14. 
Lei M, Cheng IH, Roberts LA, McAlear MA, Tye BK. Two mcm3 mutations affect different steps in the initiation of DNA replication.
J Biol Chem. 2002 Aug 23;277(34):30824-31.